Best Anti-wrinkle and Anti-aging Topical Products used together with Derma Rollers

When you look at the mirror, does it remind you that years are passing by so quickly? Are you seeing some signs of aging that gives you some panic attacks? Growing old is a process that you can get away with, no matter what you do.

Aging is a complex biological process that is influenced by a combination of extrinsic and intrinsic factors. [1]For the extrinsic factors it includes:

  • Chronic Light or Sun exposure
  • Pollution
  • Ionizing Radiation
  • Toxins
  • Chemicals

For the intrinsic factors it includes:

  • Genetics
  • Hormone
  • Metabolic Processes
  • Cellular metabolism

These factors cause physiological and structural changes on your skin layers. The skin is the first organ that manifests the aging process. It can be seen as the obvious signs of aging such as appearance of wrinkles, fine lines and skin sagging that makes your skin look old and gloomy, both for men and women.

lines-and-wrinkles derma-roller-before-after

But you can do something to delay the process and that is through healthy lifestyle, regular exercise, and use of skin care products that helps rejuvenate your skin.  But what is more effective, are the new and emerging skin care treatments that promises optimum and faster results, plus relatively easy and cheaper procedure.

One of the popular emerging skin care treatment used to remove wrinkles and other fine lines is the derma rolling or microneedling therapy.

So, how does microneedling or dermarolling therapy removes wrinkles?

Microneedling is a skin resurfacing procedure that involves the use of micro needles to create superficial injury.

These micro injuries induce the remodeling of the existing collagen that is used to promote formation of new collagen and elastin. [2]  It also promotes vascularization or formation of new blood vessels in the papillary dermis. This results to reduction in the appearance of wrinkles and fine lines. It is also used to treat acne, scars, skin pigmentation and other skin conditions. Derma rolling treatment has become the treatment of choice for patients with ethnic skin types or those with thin and sensitive skins.

Recent studies showed that microneedling treatment helps reduce wrinkles and improve the appearance of scars.  Results indicates that microneedling help reduce skin aging around the neck area and also help reduce wrinkles. In the study, the patients undergo two treatment sessions of microneedling.  The final analysis showed that 90% of the patients showed improvement in their wrinkles and reduction in the irregularity of the skin surface.[3]

eyes wrinkles

Microneedling is also being used for transdermal delivery of topical drugs for a more effective result. This therapy works by creating channels through the stratum corneum found in the epidermis. And this allows a faster and more efficient delivery of topical drugs through the layers of the skin.

The microneedles have different design and composition to assists the faster delivery of the drugs. [4]The four categories of micro needles include:

  • Solid microneedles to for skin pretreatment
  • Drug-coated microneedles
  • Dissolving or biodegradable microneedles
  • Hollow microneedles


Best Anti-wrinkle products Used together with Derma Rollers


There are a number of anti-wrinkle products that are being used together with derma rolling therapy. There are two main agents that are used as anti-aging components that removes the different signs of aging:



The antioxidants include:

  • Vitamins
  • Flavonoids
  • Polyphenols

Vitamin C serum is a popular choice among dermatologist as a topical agent used together with derma rolling therapy. Vitamins help reduce the collagen degradation by lessening the proliferation of free radicals which are harmful to the cells in the body.

Ascorbic acid or vitamin C is a heat labile and water soluble vitamin. 1 A concentration between 5 to 15% is proven to have anti-aging properties by producing Col-1 and Col-3.  It also stimulates the production of enzymes that are important in the production of collagen and inhibits matrixmetalloproteinase (MMP) 1 or collagenase 1.

Cell Regulators

The cell regulators include:

  • Retinols or Vitamin A derivatives
  • Peptides and botanicals
  • Growth factors

These compounds have direct effect on the collagen metabolism. It also influences the production of elastic fibers and collagen. 1

Vitamin A or Retinol is used as topical agent in derma rolling therapy. Other agents of vitamin A such as retinoid and retinaldehyde are known for its antioxidant effects. These agents work by stimulating the synthesis of collagen.

It also helps reduce the expression of MMP 1 or collagenase 1.  Retinol is the most often used anti-aging compound and it causes lesser skin irritation than tretinoin. Studies have shown that it has positive effects on collagen metabolism.

In the United States, tretinoin, a non-aromatic retinoid, is currently approved for anti-aging treatment with a concentration of 0.05%.

Derma rolling therapy is an in-office procedure used to resurface the epidermis. This means removing the damaged epidermis and replacing it with a remodeled skin layer. It also help stimulates the formation of new collagen.1

A combination therapy of microneedling or dermarolling plus topical agents is a powerful duo that helps your skin look younger.  It removes or reduces wrinkles, fine lines and sagging skin. If you want to look younger than your age, this one of the best treatment option because it’s simple, cheap, and offers immediate results.


[1] Ruta Ganceviciene , † Aikaterini I. Liakou , † Athanasios Theodoridis, Evgenia Makrantonaki, and Christos C. Zouboulis . (2012). Skin anti-aging strategies. Dermatoendocrinol. , 308–319

[2] Mathew M Loesch, Ally-Khan Somani,Melanie M Kingsley,Jeffrey B Travers, and Dan F Spandau. (2014). Skin resurfacing procedures: new and emerging options. Clin Cosmet Investig Dermatol. , 231–241.

[3] Fabbrocini G1, De Vita V, Di Costanzo L, Pastore F, Mauriello MC, Ambra M, Annunziata MC, di Santolo MG, Cameli N, Monfrecola G. (2011). Skin needling in the treatment of the aging neck. Skinmed. , 347-51.

[4] Gratieri T, Alberti I, Lapteva M, Kalia YN. (2013). Next generation intra- and transdermal therapeutic systems: using non- and minimally-invasive technologies to increase drug delivery into and across the skin. Eur J Pharm Sci. , 609-22.

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